HCC Total Tumour Volume Transplant Criteria Calculator

This is an app to calculate total tumour volume (TTV) of hepatocellular carcinoma to see if patients meet criteria for liver transplantation. The user would enter the diameters (in cm) for each of the tumour. The user would also enter the AFP level in ng/ml. The app calculates the TTV in cm3.

The app also determines whether the tumours are within the HCC TTV, Milan, and UCSF criteria.


App developed by

Kris P. Croome, MD, MS
The University of Western Ontario
Multi-Organ Transplant Program, London Health Sciences Centre
Department of Surgery, Division of General Surgery
London, Ontario
Canada


Marc L. Melcher, MD, PhD
Department of Surgery
Division of Abdominal Transplantation
Stanford University
Palo Alto, CA
United States

References:

Mazzaferro V, Regalia E, Doci R, Andreoli S, Pulvirenti A, Bozzetti F, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med. 1996;334:693-699.

Yao FY, Ferrell L, Bass NM, et al. Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival. Hepatology. 2001;33(6):1394–1403.

Toso C, Trotter J, Wei A, Bigam DL, ShahS, Lancaster J, Grant DR, Greig PD,3 Shapiro AMJ, Kneteman NM. Total Tumor Volume Predicts Risk of Recurrence Following Liver Transplantation in Patients with Hepatocellular Carcinoma. Liver Transplantation 2008: 14:1107-1115.